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alaT [2017-8-11 16:0:3]
similar to PLP-dependent methionine aminotransferase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.15|Biosynthesis/acquisition of L- and D-alanine]Gene
Coordinates
3,225,772 → 3,226,932
The protein
Paralogous protein(s)
[protein|094AE3AC8DFAFC8048ADAAB34F76DF2562D80CE7|PatA](45%), [protein|8F7432F7EF0F767C6000D553A3ACE29FBA2EDCEE|YhdR]Structure
[PDB|1DJU] (from ''Pyrococcus horikoshii'', 47% identity) [Pubmed|10671523]Additional information
The gene is annotated in KEGG as an ortholog of N-succinyldiaminopimelate aminotransferase EC 2.6.1.17. It is annotated in Swiss-Prot as “alanine transaminase”. In MetaCyc the gene is marked as “similar to aspartateaminotransferase”. No literature/experimental evidence supporting the annotation is available. [Pubmed|19935659]Expression and Regulation
Operons
genes
[gene|1CA87275AFA1B4E4B5E8E10229009F785E70BBA8|alaR]-[gene|62A9CD9AF72D0A48EC5ABC1585E2D8636D36D021|alaT]
description
[Pubmed|22383849]
additional information
A [protein|search|ncRNA] is predicted between [gene|B0908BB4B8B569A7A78BB0B84784FD4C427C598B|yugI] and [gene|62A9CD9AF72D0A48EC5ABC1585E2D8636D36D021|alaT] [PubMed|20525796]view in new tabBiological materials
Mutant
MGNA-A621 (yugH::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/621 NBRP B. subtilis, Japan]References
20525796,22383849,10671523